Transcriptomic responses of Phanerochaete chrysosporium to oak acetonic extracts: focus on a new glutathione transferase.
Identifieur interne : 001435 ( Main/Exploration ); précédent : 001434; suivant : 001436Transcriptomic responses of Phanerochaete chrysosporium to oak acetonic extracts: focus on a new glutathione transferase.
Auteurs : Anne Thuillier [France] ; Kamel Chibani [France] ; Gemma Belli [Espagne] ; Enrique Herrero [Espagne] ; Stéphane Dumarçay [France] ; Philippe Gérardin [France] ; Annegret Kohler [France] ; Aurélie Deroy [France] ; Tiphaine Dhalleine [France] ; Raphael Bchini [France] ; Jean-Pierre Jacquot [France] ; Eric Gelhaye [France] ; Mélanie Morel-Rouhier [France]Source :
- Applied and environmental microbiology [ 1098-5336 ] ; 2014.
Descripteurs français
- KwdFr :
- Acétone (composition chimique), Bois (microbiologie), Extraits de plantes (composition chimique), Extraits de plantes (pharmacologie), Glutathione transferase (génétique), Glutathione transferase (métabolisme), Inactivation métabolique (MeSH), Isoenzymes (MeSH), Lignine (métabolisme), Peroxydation lipidique (MeSH), Peroxydes (composition chimique), Peroxydes (métabolisme), Phanerochaete (effets des médicaments et des substances chimiques), Phanerochaete (génétique), Phanerochaete (métabolisme), Protéines recombinantes (génétique), Protéines recombinantes (métabolisme), Quercus (composition chimique), Régulation de l'expression des gènes fongiques (MeSH), Saccharomyces cerevisiae (génétique), Saccharomyces cerevisiae (métabolisme), Stress oxydatif (effets des médicaments et des substances chimiques), Évolution moléculaire (MeSH).
- MESH :
- composition chimique : Acétone, Extraits de plantes, Peroxydes, Quercus.
- effets des médicaments et des substances chimiques : Phanerochaete, Stress oxydatif.
- génétique : Glutathione transferase, Phanerochaete, Protéines recombinantes, Saccharomyces cerevisiae.
- microbiologie : Bois.
- métabolisme : Glutathione transferase, Lignine, Peroxydes, Phanerochaete, Protéines recombinantes, Saccharomyces cerevisiae.
- pharmacologie : Extraits de plantes.
- Inactivation métabolique, Isoenzymes, Peroxydation lipidique, Régulation de l'expression des gènes fongiques, Évolution moléculaire.
English descriptors
- KwdEn :
- Acetone (chemistry), Evolution, Molecular (MeSH), Gene Expression Regulation, Fungal (MeSH), Glutathione Transferase (genetics), Glutathione Transferase (metabolism), Inactivation, Metabolic (MeSH), Isoenzymes (MeSH), Lignin (metabolism), Lipid Peroxidation (MeSH), Oxidative Stress (drug effects), Peroxides (chemistry), Peroxides (metabolism), Phanerochaete (drug effects), Phanerochaete (genetics), Phanerochaete (metabolism), Plant Extracts (chemistry), Plant Extracts (pharmacology), Quercus (chemistry), Recombinant Proteins (genetics), Recombinant Proteins (metabolism), Saccharomyces cerevisiae (genetics), Saccharomyces cerevisiae (metabolism), Wood (microbiology).
- MESH :
- chemical , chemistry : Acetone, Peroxides, Plant Extracts.
- chemical , genetics : Glutathione Transferase, Recombinant Proteins.
- chemical , metabolism : Glutathione Transferase, Lignin, Peroxides, Recombinant Proteins.
- chemistry : Quercus.
- drug effects : Oxidative Stress, Phanerochaete.
- genetics : Phanerochaete, Saccharomyces cerevisiae.
- metabolism : Phanerochaete, Saccharomyces cerevisiae.
- microbiology : Wood.
- chemical , pharmacology : Plant Extracts.
- Evolution, Molecular, Gene Expression Regulation, Fungal, Inactivation, Metabolic, Isoenzymes, Lipid Peroxidation.
Abstract
The first steps of wood degradation by fungi lead to the release of toxic compounds known as extractives. To better understand how lignolytic fungi cope with the toxicity of these molecules, a transcriptomic analysis of Phanerochaete chrysosporium genes was performed in the presence of oak acetonic extracts. It reveals that in complement to the extracellular machinery of degradation, intracellular antioxidant and detoxification systems contribute to the lignolytic capabilities of fungi, presumably by preventing cellular damages and maintaining fungal health. Focusing on these systems, a glutathione transferase (P. chrysosporium GTT2.1 [PcGTT2.1]) has been selected for functional characterization. This enzyme, not characterized so far in basidiomycetes, has been classified first as a GTT2 compared to the Saccharomyces cerevisiae isoform. However, a deeper analysis shows that the GTT2.1 isoform has evolved functionally to reduce lipid peroxidation by recognizing high-molecular-weight peroxides as substrates. Moreover, the GTT2.1 gene has been lost in some non-wood-decay fungi. This example suggests that the intracellular detoxification system evolved concomitantly with the extracellular ligninolytic machinery in relation to the capacity of fungi to degrade wood.
DOI: 10.1128/AEM.02103-14
PubMed: 25107961
PubMed Central: PMC4178660
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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sortKey="Jacquot, Jean Pierre" sort="Jacquot, Jean Pierre" uniqKey="Jacquot J" first="Jean-Pierre" last="Jacquot">Jean-Pierre Jacquot</name><affiliation wicri:level="4"><nlm:affiliation>Université de Lorraine, IAM, UMR 1136, IFR 110 EFABA, Champenoux, France INRA, IAM, UMR 1136, Vandoeuvre-les-Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université de Lorraine, IAM, UMR 1136, IFR 110 EFABA, Champenoux, France INRA, IAM, UMR 1136, Vandoeuvre-les-Nancy</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region><settlement type="city">Vandœuvre-lès-Nancy</settlement><settlement type="city" wicri:auto="agglo">Nancy</settlement></placeName><orgName type="university">Université de Lorraine</orgName></affiliation></author><author><name sortKey="Gelhaye, Eric" sort="Gelhaye, Eric" uniqKey="Gelhaye E" first="Eric" last="Gelhaye">Eric Gelhaye</name><affiliation wicri:level="4"><nlm:affiliation>Université de Lorraine, IAM, UMR 1136, IFR 110 EFABA, Champenoux, France INRA, IAM, UMR 1136, Vandoeuvre-les-Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université de Lorraine, IAM, UMR 1136, IFR 110 EFABA, Champenoux, France INRA, IAM, UMR 1136, Vandoeuvre-les-Nancy</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region><settlement type="city">Vandœuvre-lès-Nancy</settlement><settlement type="city" wicri:auto="agglo">Nancy</settlement></placeName><orgName type="university">Université de Lorraine</orgName></affiliation></author><author><name sortKey="Morel Rouhier, Melanie" sort="Morel Rouhier, Melanie" uniqKey="Morel Rouhier M" first="Mélanie" last="Morel-Rouhier">Mélanie Morel-Rouhier</name><affiliation wicri:level="4"><nlm:affiliation>Université de Lorraine, IAM, UMR 1136, IFR 110 EFABA, Champenoux, France INRA, IAM, UMR 1136, Vandoeuvre-les-Nancy, France Melanie.Morel@univ-lorraine.fr.</nlm:affiliation><country wicri:rule="url">France</country><wicri:regionArea>Université de Lorraine, IAM, UMR 1136, IFR 110 EFABA, Champenoux, France INRA, IAM, UMR 1136, Vandoeuvre-les-Nancy</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region><settlement type="city">Vandœuvre-lès-Nancy</settlement><settlement type="city" wicri:auto="agglo">Nancy</settlement></placeName><orgName type="university">Université de Lorraine</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:25107961</idno><idno type="pmid">25107961</idno><idno type="doi">10.1128/AEM.02103-14</idno><idno type="pmc">PMC4178660</idno><idno type="wicri:Area/Main/Corpus">001469</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" 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Est</region><region type="old region" nuts="2">Lorraine (région)</region><settlement type="city">Vandœuvre-lès-Nancy</settlement><settlement type="city" wicri:auto="agglo">Nancy</settlement></placeName><orgName type="university">Université de Lorraine</orgName></affiliation></author><author><name sortKey="Chibani, Kamel" sort="Chibani, Kamel" uniqKey="Chibani K" first="Kamel" last="Chibani">Kamel Chibani</name><affiliation wicri:level="4"><nlm:affiliation>Université de Lorraine, IAM, UMR 1136, IFR 110 EFABA, Champenoux, France INRA, IAM, UMR 1136, Vandoeuvre-les-Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université de Lorraine, IAM, UMR 1136, IFR 110 EFABA, Champenoux, France INRA, IAM, UMR 1136, Vandoeuvre-les-Nancy</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region><settlement type="city">Vandœuvre-lès-Nancy</settlement><settlement type="city" wicri:auto="agglo">Nancy</settlement></placeName><orgName type="university">Université de Lorraine</orgName></affiliation></author><author><name sortKey="Belli, Gemma" sort="Belli, Gemma" uniqKey="Belli G" first="Gemma" last="Belli">Gemma Belli</name><affiliation wicri:level="1"><nlm:affiliation>Departament de Ciències Mèdiques Bàsiques, Universitat de Lleida, IRB Lleida, Lleida, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departament de Ciències Mèdiques Bàsiques, Universitat de Lleida, IRB Lleida, Lleida</wicri:regionArea><wicri:noRegion>Lleida</wicri:noRegion></affiliation></author><author><name sortKey="Herrero, Enrique" sort="Herrero, Enrique" uniqKey="Herrero E" first="Enrique" last="Herrero">Enrique Herrero</name><affiliation wicri:level="1"><nlm:affiliation>Departament de Ciències Mèdiques Bàsiques, Universitat de Lleida, IRB Lleida, Lleida, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departament de Ciències Mèdiques Bàsiques, Universitat de Lleida, IRB Lleida, Lleida</wicri:regionArea><wicri:noRegion>Lleida</wicri:noRegion></affiliation></author><author><name sortKey="Dumarcay, Stephane" sort="Dumarcay, Stephane" uniqKey="Dumarcay S" first="Stéphane" last="Dumarçay">Stéphane Dumarçay</name><affiliation wicri:level="4"><nlm:affiliation>Université de Lorraine, LERMAB, UMR 1093, Faculté des Sciences et Technologies, Vandoeuvre-lès-Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université de Lorraine, LERMAB, UMR 1093, Faculté des Sciences et Technologies, Vandoeuvre-lès-Nancy</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region><settlement type="city">Vandœuvre-lès-Nancy</settlement><settlement type="city" wicri:auto="agglo">Nancy</settlement></placeName><orgName type="university">Université de Lorraine</orgName></affiliation></author><author><name sortKey="Gerardin, Philippe" sort="Gerardin, Philippe" uniqKey="Gerardin P" first="Philippe" last="Gérardin">Philippe Gérardin</name><affiliation wicri:level="4"><nlm:affiliation>Université de Lorraine, LERMAB, UMR 1093, Faculté des Sciences et Technologies, Vandoeuvre-lès-Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université de Lorraine, LERMAB, UMR 1093, Faculté des Sciences et Technologies, Vandoeuvre-lès-Nancy</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region><settlement type="city">Vandœuvre-lès-Nancy</settlement><settlement type="city" wicri:auto="agglo">Nancy</settlement></placeName><orgName type="university">Université de Lorraine</orgName></affiliation></author><author><name sortKey="Kohler, Annegret" sort="Kohler, Annegret" uniqKey="Kohler A" first="Annegret" last="Kohler">Annegret Kohler</name><affiliation wicri:level="4"><nlm:affiliation>Université de Lorraine, IAM, UMR 1136, IFR 110 EFABA, Champenoux, France INRA, IAM, UMR 1136, Vandoeuvre-les-Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université de Lorraine, IAM, UMR 1136, IFR 110 EFABA, Champenoux, France INRA, IAM, UMR 1136, Vandoeuvre-les-Nancy</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region><settlement type="city">Vandœuvre-lès-Nancy</settlement><settlement type="city" wicri:auto="agglo">Nancy</settlement></placeName><orgName type="university">Université de Lorraine</orgName></affiliation></author><author><name sortKey="Deroy, Aurelie" sort="Deroy, Aurelie" uniqKey="Deroy A" first="Aurélie" last="Deroy">Aurélie Deroy</name><affiliation wicri:level="4"><nlm:affiliation>Université de Lorraine, IAM, UMR 1136, IFR 110 EFABA, Champenoux, France INRA, IAM, UMR 1136, Vandoeuvre-les-Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université de Lorraine, IAM, UMR 1136, IFR 110 EFABA, Champenoux, France INRA, IAM, UMR 1136, Vandoeuvre-les-Nancy</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region><settlement type="city">Vandœuvre-lès-Nancy</settlement><settlement type="city" wicri:auto="agglo">Nancy</settlement></placeName><orgName type="university">Université de Lorraine</orgName></affiliation></author><author><name sortKey="Dhalleine, Tiphaine" sort="Dhalleine, Tiphaine" uniqKey="Dhalleine T" first="Tiphaine" last="Dhalleine">Tiphaine Dhalleine</name><affiliation wicri:level="4"><nlm:affiliation>Université de Lorraine, IAM, UMR 1136, IFR 110 EFABA, Champenoux, France INRA, IAM, UMR 1136, Vandoeuvre-les-Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université de Lorraine, IAM, UMR 1136, IFR 110 EFABA, Champenoux, France INRA, IAM, UMR 1136, Vandoeuvre-les-Nancy</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region><settlement type="city">Vandœuvre-lès-Nancy</settlement><settlement type="city" wicri:auto="agglo">Nancy</settlement></placeName><orgName type="university">Université de Lorraine</orgName></affiliation></author><author><name sortKey="Bchini, Raphael" sort="Bchini, Raphael" uniqKey="Bchini R" first="Raphael" last="Bchini">Raphael Bchini</name><affiliation wicri:level="4"><nlm:affiliation>Université de Lorraine, IAM, UMR 1136, IFR 110 EFABA, Champenoux, France INRA, IAM, UMR 1136, Vandoeuvre-les-Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université de Lorraine, IAM, UMR 1136, IFR 110 EFABA, Champenoux, France INRA, IAM, UMR 1136, Vandoeuvre-les-Nancy</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region><settlement type="city">Vandœuvre-lès-Nancy</settlement><settlement type="city" wicri:auto="agglo">Nancy</settlement></placeName><orgName type="university">Université de Lorraine</orgName></affiliation></author><author><name sortKey="Jacquot, Jean Pierre" sort="Jacquot, Jean Pierre" uniqKey="Jacquot J" first="Jean-Pierre" last="Jacquot">Jean-Pierre Jacquot</name><affiliation wicri:level="4"><nlm:affiliation>Université de Lorraine, IAM, UMR 1136, IFR 110 EFABA, Champenoux, France INRA, IAM, UMR 1136, Vandoeuvre-les-Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université de Lorraine, IAM, UMR 1136, IFR 110 EFABA, Champenoux, France INRA, IAM, UMR 1136, Vandoeuvre-les-Nancy</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region><settlement type="city">Vandœuvre-lès-Nancy</settlement><settlement type="city" wicri:auto="agglo">Nancy</settlement></placeName><orgName type="university">Université de Lorraine</orgName></affiliation></author><author><name sortKey="Gelhaye, Eric" sort="Gelhaye, Eric" uniqKey="Gelhaye E" first="Eric" last="Gelhaye">Eric Gelhaye</name><affiliation wicri:level="4"><nlm:affiliation>Université de Lorraine, IAM, UMR 1136, IFR 110 EFABA, Champenoux, France INRA, IAM, UMR 1136, Vandoeuvre-les-Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université de Lorraine, IAM, UMR 1136, IFR 110 EFABA, Champenoux, France INRA, IAM, UMR 1136, Vandoeuvre-les-Nancy</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region><settlement type="city">Vandœuvre-lès-Nancy</settlement><settlement type="city" wicri:auto="agglo">Nancy</settlement></placeName><orgName type="university">Université de Lorraine</orgName></affiliation></author><author><name sortKey="Morel Rouhier, Melanie" sort="Morel Rouhier, Melanie" uniqKey="Morel Rouhier M" first="Mélanie" last="Morel-Rouhier">Mélanie Morel-Rouhier</name><affiliation wicri:level="4"><nlm:affiliation>Université de Lorraine, IAM, UMR 1136, IFR 110 EFABA, Champenoux, France INRA, IAM, UMR 1136, Vandoeuvre-les-Nancy, France Melanie.Morel@univ-lorraine.fr.</nlm:affiliation><country wicri:rule="url">France</country><wicri:regionArea>Université de Lorraine, IAM, UMR 1136, IFR 110 EFABA, Champenoux, France INRA, IAM, UMR 1136, Vandoeuvre-les-Nancy</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region><settlement type="city">Vandœuvre-lès-Nancy</settlement><settlement type="city" wicri:auto="agglo">Nancy</settlement></placeName><orgName type="university">Université de Lorraine</orgName></affiliation></author></analytic><series><title level="j">Applied and environmental microbiology</title><idno type="eISSN">1098-5336</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acetone (chemistry)</term><term>Evolution, Molecular (MeSH)</term><term>Gene Expression Regulation, Fungal (MeSH)</term><term>Glutathione Transferase (genetics)</term><term>Glutathione Transferase (metabolism)</term><term>Inactivation, Metabolic (MeSH)</term><term>Isoenzymes (MeSH)</term><term>Lignin (metabolism)</term><term>Lipid Peroxidation (MeSH)</term><term>Oxidative Stress (drug effects)</term><term>Peroxides (chemistry)</term><term>Peroxides (metabolism)</term><term>Phanerochaete (drug effects)</term><term>Phanerochaete (genetics)</term><term>Phanerochaete (metabolism)</term><term>Plant Extracts (chemistry)</term><term>Plant Extracts (pharmacology)</term><term>Quercus (chemistry)</term><term>Recombinant Proteins (genetics)</term><term>Recombinant Proteins (metabolism)</term><term>Saccharomyces cerevisiae (genetics)</term><term>Saccharomyces cerevisiae (metabolism)</term><term>Wood (microbiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acétone (composition chimique)</term><term>Bois (microbiologie)</term><term>Extraits de plantes (composition chimique)</term><term>Extraits de plantes (pharmacologie)</term><term>Glutathione transferase (génétique)</term><term>Glutathione transferase (métabolisme)</term><term>Inactivation métabolique (MeSH)</term><term>Isoenzymes (MeSH)</term><term>Lignine (métabolisme)</term><term>Peroxydation lipidique (MeSH)</term><term>Peroxydes (composition chimique)</term><term>Peroxydes (métabolisme)</term><term>Phanerochaete (effets des médicaments et des substances chimiques)</term><term>Phanerochaete (génétique)</term><term>Phanerochaete (métabolisme)</term><term>Protéines recombinantes (génétique)</term><term>Protéines recombinantes (métabolisme)</term><term>Quercus (composition chimique)</term><term>Régulation de l'expression des gènes fongiques (MeSH)</term><term>Saccharomyces cerevisiae (génétique)</term><term>Saccharomyces cerevisiae (métabolisme)</term><term>Stress oxydatif (effets des médicaments et des substances chimiques)</term><term>Évolution moléculaire (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Acetone</term><term>Peroxides</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Glutathione Transferase</term><term>Recombinant Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Glutathione Transferase</term><term>Lignin</term><term>Peroxides</term><term>Recombinant Proteins</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Quercus</term></keywords><keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Acétone</term><term>Extraits de plantes</term><term>Peroxydes</term><term>Quercus</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Oxidative Stress</term><term>Phanerochaete</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Phanerochaete</term><term>Stress oxydatif</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Phanerochaete</term><term>Saccharomyces cerevisiae</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Glutathione transferase</term><term>Phanerochaete</term><term>Protéines recombinantes</term><term>Saccharomyces cerevisiae</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Phanerochaete</term><term>Saccharomyces cerevisiae</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Bois</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Wood</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Glutathione transferase</term><term>Lignine</term><term>Peroxydes</term><term>Phanerochaete</term><term>Protéines recombinantes</term><term>Saccharomyces cerevisiae</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Extraits de plantes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Plant Extracts</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Evolution, Molecular</term><term>Gene Expression Regulation, Fungal</term><term>Inactivation, Metabolic</term><term>Isoenzymes</term><term>Lipid Peroxidation</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Inactivation métabolique</term><term>Isoenzymes</term><term>Peroxydation lipidique</term><term>Régulation de l'expression des gènes fongiques</term><term>Évolution moléculaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The first steps of wood degradation by fungi lead to the release of toxic compounds known as extractives. To better understand how lignolytic fungi cope with the toxicity of these molecules, a transcriptomic analysis of Phanerochaete chrysosporium genes was performed in the presence of oak acetonic extracts. It reveals that in complement to the extracellular machinery of degradation, intracellular antioxidant and detoxification systems contribute to the lignolytic capabilities of fungi, presumably by preventing cellular damages and maintaining fungal health. Focusing on these systems, a glutathione transferase (P. chrysosporium GTT2.1 [PcGTT2.1]) has been selected for functional characterization. This enzyme, not characterized so far in basidiomycetes, has been classified first as a GTT2 compared to the Saccharomyces cerevisiae isoform. However, a deeper analysis shows that the GTT2.1 isoform has evolved functionally to reduce lipid peroxidation by recognizing high-molecular-weight peroxides as substrates. Moreover, the GTT2.1 gene has been lost in some non-wood-decay fungi. This example suggests that the intracellular detoxification system evolved concomitantly with the extracellular ligninolytic machinery in relation to the capacity of fungi to degrade wood. </div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25107961</PMID><DateCompleted><Year>2016</Year><Month>04</Month><Day>14</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1098-5336</ISSN><JournalIssue CitedMedium="Internet"><Volume>80</Volume><Issue>20</Issue><PubDate><Year>2014</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Applied and environmental microbiology</Title><ISOAbbreviation>Appl Environ Microbiol</ISOAbbreviation></Journal><ArticleTitle>Transcriptomic responses of Phanerochaete chrysosporium to oak acetonic extracts: focus on a new glutathione transferase.</ArticleTitle><Pagination><MedlinePgn>6316-27</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1128/AEM.02103-14</ELocationID><Abstract><AbstractText>The first steps of wood degradation by fungi lead to the release of toxic compounds known as extractives. To better understand how lignolytic fungi cope with the toxicity of these molecules, a transcriptomic analysis of Phanerochaete chrysosporium genes was performed in the presence of oak acetonic extracts. It reveals that in complement to the extracellular machinery of degradation, intracellular antioxidant and detoxification systems contribute to the lignolytic capabilities of fungi, presumably by preventing cellular damages and maintaining fungal health. Focusing on these systems, a glutathione transferase (P. chrysosporium GTT2.1 [PcGTT2.1]) has been selected for functional characterization. This enzyme, not characterized so far in basidiomycetes, has been classified first as a GTT2 compared to the Saccharomyces cerevisiae isoform. However, a deeper analysis shows that the GTT2.1 isoform has evolved functionally to reduce lipid peroxidation by recognizing high-molecular-weight peroxides as substrates. Moreover, the GTT2.1 gene has been lost in some non-wood-decay fungi. This example suggests that the intracellular detoxification system evolved concomitantly with the extracellular ligninolytic machinery in relation to the capacity of fungi to degrade wood. </AbstractText><CopyrightInformation>Copyright © 2014, American Society for Microbiology. All Rights Reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Thuillier</LastName><ForeName>Anne</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Université de Lorraine, IAM, UMR 1136, IFR 110 EFABA, Champenoux, France INRA, IAM, UMR 1136, Vandoeuvre-les-Nancy, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chibani</LastName><ForeName>Kamel</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Université de Lorraine, IAM, UMR 1136, IFR 110 EFABA, Champenoux, France INRA, IAM, UMR 1136, Vandoeuvre-les-Nancy, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Belli</LastName><ForeName>Gemma</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Departament de Ciències Mèdiques Bàsiques, Universitat de Lleida, IRB Lleida, Lleida, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Herrero</LastName><ForeName>Enrique</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Departament de Ciències Mèdiques Bàsiques, Universitat de Lleida, IRB Lleida, Lleida, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dumarçay</LastName><ForeName>Stéphane</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Université de Lorraine, LERMAB, UMR 1093, Faculté des Sciences et Technologies, Vandoeuvre-lès-Nancy, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gérardin</LastName><ForeName>Philippe</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Université de Lorraine, LERMAB, UMR 1093, Faculté des Sciences et Technologies, Vandoeuvre-lès-Nancy, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kohler</LastName><ForeName>Annegret</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Université de Lorraine, IAM, UMR 1136, IFR 110 EFABA, Champenoux, France INRA, IAM, UMR 1136, Vandoeuvre-les-Nancy, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Deroy</LastName><ForeName>Aurélie</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Université de Lorraine, IAM, UMR 1136, IFR 110 EFABA, Champenoux, France INRA, IAM, UMR 1136, Vandoeuvre-les-Nancy, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dhalleine</LastName><ForeName>Tiphaine</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Université de Lorraine, IAM, UMR 1136, IFR 110 EFABA, Champenoux, France INRA, IAM, UMR 1136, Vandoeuvre-les-Nancy, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bchini</LastName><ForeName>Raphael</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Université de Lorraine, IAM, UMR 1136, IFR 110 EFABA, Champenoux, France INRA, IAM, UMR 1136, Vandoeuvre-les-Nancy, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jacquot</LastName><ForeName>Jean-Pierre</ForeName><Initials>JP</Initials><AffiliationInfo><Affiliation>Université de Lorraine, IAM, UMR 1136, IFR 110 EFABA, Champenoux, France INRA, IAM, UMR 1136, Vandoeuvre-les-Nancy, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gelhaye</LastName><ForeName>Eric</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Université de Lorraine, IAM, UMR 1136, IFR 110 EFABA, Champenoux, France INRA, IAM, UMR 1136, Vandoeuvre-les-Nancy, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Morel-Rouhier</LastName><ForeName>Mélanie</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Université de Lorraine, IAM, UMR 1136, IFR 110 EFABA, Champenoux, France INRA, IAM, UMR 1136, Vandoeuvre-les-Nancy, France Melanie.Morel@univ-lorraine.fr.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><DataBankList CompleteYN="Y"><DataBank><DataBankName>GEO</DataBankName><AccessionNumberList><AccessionNumber>GSE54542</AccessionNumber></AccessionNumberList></DataBank></DataBankList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>08</Month><Day>08</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Appl Environ Microbiol</MedlineTA><NlmUniqueID>7605801</NlmUniqueID><ISSNLinking>0099-2240</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007527">Isoenzymes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010545">Peroxides</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010936">Plant Extracts</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011994">Recombinant Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>11132-73-3</RegistryNumber><NameOfSubstance UI="C036909">lignocellulose</NameOfSubstance></Chemical><Chemical><RegistryNumber>1364PS73AF</RegistryNumber><NameOfSubstance UI="D000096">Acetone</NameOfSubstance></Chemical><Chemical><RegistryNumber>9005-53-2</RegistryNumber><NameOfSubstance UI="D008031">Lignin</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.5.1.18</RegistryNumber><NameOfSubstance UI="D005982">Glutathione Transferase</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000096" MajorTopicYN="N">Acetone</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019143" MajorTopicYN="N">Evolution, Molecular</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015966" MajorTopicYN="N">Gene Expression Regulation, Fungal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005982" MajorTopicYN="N">Glutathione Transferase</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008658" MajorTopicYN="N">Inactivation, Metabolic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007527" MajorTopicYN="N">Isoenzymes</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008031" MajorTopicYN="N">Lignin</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015227" MajorTopicYN="N">Lipid Peroxidation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018384" MajorTopicYN="N">Oxidative Stress</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010545" MajorTopicYN="N">Peroxides</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020075" MajorTopicYN="N">Phanerochaete</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010936" MajorTopicYN="N">Plant Extracts</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D029963" MajorTopicYN="N">Quercus</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011994" MajorTopicYN="N">Recombinant Proteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012441" MajorTopicYN="N">Saccharomyces cerevisiae</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014934" MajorTopicYN="N">Wood</DescriptorName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>8</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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name="France"><region name="Grand Est"><name sortKey="Thuillier, Anne" sort="Thuillier, Anne" uniqKey="Thuillier A" first="Anne" last="Thuillier">Anne Thuillier</name></region><name sortKey="Bchini, Raphael" sort="Bchini, Raphael" uniqKey="Bchini R" first="Raphael" last="Bchini">Raphael Bchini</name><name sortKey="Chibani, Kamel" sort="Chibani, Kamel" uniqKey="Chibani K" first="Kamel" last="Chibani">Kamel Chibani</name><name sortKey="Deroy, Aurelie" sort="Deroy, Aurelie" uniqKey="Deroy A" first="Aurélie" last="Deroy">Aurélie Deroy</name><name sortKey="Dhalleine, Tiphaine" sort="Dhalleine, Tiphaine" uniqKey="Dhalleine T" first="Tiphaine" last="Dhalleine">Tiphaine Dhalleine</name><name sortKey="Dumarcay, Stephane" sort="Dumarcay, Stephane" uniqKey="Dumarcay S" first="Stéphane" last="Dumarçay">Stéphane Dumarçay</name><name sortKey="Gelhaye, Eric" sort="Gelhaye, Eric" uniqKey="Gelhaye E" first="Eric" last="Gelhaye">Eric Gelhaye</name><name sortKey="Gerardin, Philippe" sort="Gerardin, Philippe" uniqKey="Gerardin P" first="Philippe" last="Gérardin">Philippe Gérardin</name><name sortKey="Jacquot, Jean Pierre" sort="Jacquot, Jean Pierre" uniqKey="Jacquot J" first="Jean-Pierre" last="Jacquot">Jean-Pierre Jacquot</name><name sortKey="Kohler, Annegret" sort="Kohler, Annegret" uniqKey="Kohler A" first="Annegret" last="Kohler">Annegret Kohler</name><name sortKey="Morel Rouhier, Melanie" sort="Morel Rouhier, Melanie" uniqKey="Morel Rouhier M" first="Mélanie" last="Morel-Rouhier">Mélanie Morel-Rouhier</name></country><country name="Espagne"><noRegion><name sortKey="Belli, Gemma" sort="Belli, Gemma" uniqKey="Belli G" first="Gemma" last="Belli">Gemma Belli</name></noRegion><name sortKey="Herrero, Enrique" sort="Herrero, Enrique" uniqKey="Herrero E" first="Enrique" last="Herrero">Enrique Herrero</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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